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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4304 | Azoramide | Apoptosis , PERK | |
Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response. | |||
T7486 | Imeglimin hydrochloride | EMD 387008 hydrochloride | Reactive Oxygen Species , Mitochondrial Metabolism |
Imeglimin hydrochloride (EMD 387008 hydrochloride) prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration. | |||
T9232 | Mitochondrial fusion promoter M1 | Mitochondrial Metabolism | |
Mitochondrial fusion promoter M1, a modulator of mitochondrial dynamics, enhances mitochondrial function and cellular respiration, and has shown efficacy in reducing brain and cardiac damage in rats suffering from cardia... | |||
T3S1628 | Vitexin-4''-O-glucoside | Vitexin -4''-O-glucoside | Others |
Vitexin-4''-O-glucoside (Vitexin -4''-O-glucoside) could effectively protect ECV-304 cells against cytotoxicity induced by TBHP through resuming mitochondrial function. | |||
T39516 | Bocidelpar | PPAR | |
Bocidelpar is a modulator of PPARδ with an EC50 of 7.80 nM and improves mitochondrial biogenesis and function in Duchenne Muscular Dystrophy muscle cells. | |||
T10952 | Dabuzalgron | Ro 115-1240 | Apoptosis , Adrenergic Receptor |
Dabuzalgron (Ro 115-1240) is an orally active selective alpha-1A adrenergic receptor agonist used to treat urinary incontinence. Dabuzaron prevents cardiotoxicity caused by doxorubicin by maintaining mitochondrial functi... | |||
T3S0137 | Bavachalcone | Antibacterial , Antibiotic | |
Bavachalcone is a major bioactive compounds isolated from Psoralea corylifolia L. it may be useful as a therapeutic drug for bone resorption-associated diseases.Bavachalcone can protect the endothelial function by increa... | |||
T64755 | Ammonium Chloride | Autophagy , Antifungal | |
Ammonium chloride acts as a small molecule autophagy inhibitor.Ammonium chloride is a pH-regulating, heteropolar compound that can cause intracellular alkalosis and metabolic acidosis, thereby affecting enzyme activity a... | |||
T8678 | Naphthazarin | 5,8-Dihydroxy-1,4-naphthoquinone,DHNQ | Apoptosis |
Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, inter... | |||
T77577 | SLU-PP-332 | Estrogen/progestogen Receptor | |
SLU-PP-332 is a pan-estrogen receptor-related receptor (ERR) agonist with high affinity for ERRα, ERRβ, and ERRγ with EC50 values of 98, 230, and 430 nM, respectively.SLUPP-332 enhances mitochondrial function and cellula... | |||
T35689 | MTP 131 acetate | Others | |
MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging... | |||
T27139 | Decylubiquinone | ||
Decylubiquinone is an analog of ubiquinone. It increases mitochondrial function in synaptosomes. Decylubiquinone inhibits the redox-activated mitochondrial permeability transition. | |||
T28195 | NS004 | NS 004,NS-004 | |
NS004 is a large-conductance K+ channel opener, it inhibits mitochondrial function in glioma cells. | |||
T27210 | DRX-065 | DRX 065,DRX065,deuterated R-enantiomer of pioglitazone | |
DRX-065 is a stabilized and deuterated R-enantiomer of pioglitazone. DRX-065 has pharmacological properties desirable for the treatment of NASH (mitochondrial function modulation, non-steroidal anti-inflammatory effects,... | |||
T11661 | INT-767 | FXR , GPCR19 | |
INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function for the study of non-alcoholic steatohepatitis. | |||
T79476 | SCAL-255 | Mitochondrial Metabolism | |
SCAL-255 is a mitochondrial complex I (CI) inhibitor, exhibiting potent inhibition with an IC50 of 1.14 μM. It impedes mitochondrial function by blocking oxygen consumption rate (OCR), inducing reactive oxygen species (R... | |||
T79477 | SCAL-266 | Mitochondrial Metabolism | |
SCAL-266, a potent inhibitor of mitochondrial complex I (CI), exhibits an IC50 of 0.83 μM. This compound impairs mitochondrial function by blocking oxidative phosphorylation (OXPHOS), inhibiting oxygen consumption rate (... | |||
T74571 | TSPO Ligand-Linker Conjugates 1 | ||
TSPO Ligand-Linker Conjugates 1, comprising a translocator protein (TSPO) ligand and a linker, is instrumental in synthesizing mitochondria-targeting autophagy-targeting chimera (AUTAC). This compound binds TSPO on the o... | |||
T78624 | OPC-163493 | Reactive Oxygen Species | |
OPC-163493 is an orally active, liver-targeted mitochondrial uncoupling agent that diminishes Δψ (delta psi) and mitochondrial ROS (reactive oxygen species) production. This compound demonstrates antidiabetic properties ... | |||
T79732 | CD38 inhibitor 3 | CD38 | |
CD38 Inhibitor 3 (compound 1), with an IC50 of 11 nM, is a potent agent that enhances mitochondrial biogenesis, diminishes lactate levels, and augments both NAD+ content and Nrf2 expression. In a Pus1 -/- mouse model of ... |